LB887 Direct effects of zinc in proliferation and migration of human squamous cell carcinoma cell lines in vitro

Zinc is a trace element that requires for more than 2000 transcription factors. Thus, zinc could have functions in development, differentiation, and cell growth of many types including cancer cells. Prior studies reported induced apoptosis cells, such as glioma, bladder, prostate, breast, melanoma. Topical application high concentration containing Mohs paste effective to shrink skin cancers squamous carcinoma (SCC), breast cancer. However, the evidences direct effect migration cutaneous SCC cells are scarce. We aimed study vitro. Two lines (A431 HSC-5) were cultured serum free medium with or without different zinc. TPEN was used chelate when tumor some experiments. (1, 10, 100 μg/dl)significantly inhibits proliferation at 48 hours 72 dose dependent manner (p<0.05). Scratch assay performed test migration. Chelation by (2μM) delayed wound closure A431 On other hand, addition accelerates HSC-5 compared control condition These results demonstrate suppressive function against reducing inhibiting